Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Host response: Neurons loosen the gRIP of death

RIPK3 is a well-known mediator of the necroptosis cell death pathway, which is an important antiviral defence mechanism. In an unexpected twist, RIPK3 has now been shown to also drive neuroprotective inflammation in the central nervous system during West Nile virus infection in a cell-death-independent manner.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: RIPK3 activation drives chemokine expression in neurons, but not other cell types.

References

  1. Sridharan, H. & Upton, J. W. Trends Microbiol. 22, 199–207 (2014).

    Article  CAS  Google Scholar 

  2. Guo, H., Kaiser, W. J. & Mocarski, E. S. Med. Microbiol. Immunol. 204, 439–448 (2015).

    Article  CAS  Google Scholar 

  3. Daniels, B. P. et al. Cell 169 301–313 (2017).

    Article  CAS  Google Scholar 

  4. Suthar, M. S., Diamond, M. S. & Gale, M. Jr. Nat. Rev. Microbiol. 11, 115–128 (2013).

    Article  CAS  Google Scholar 

  5. Lim, J. K. & Murphy, P. M. Exp. Cell. Res. 317, 569–574 (2011).

    Article  CAS  Google Scholar 

  6. Orozco, S. et al. Cell Death Differ. 21, 1511–1521 (2014).

    Article  CAS  Google Scholar 

  7. Moriwaki, K., Balaji, S., Bertin, J., Gough, P. J. & Chan, F. K. Cell Rep. 18, 2441–2451 (2017).

    Article  CAS  Google Scholar 

  8. Moriwaki, K. et al. Immunity 41, 567–578 (2014).

    Article  CAS  Google Scholar 

  9. Najjar, M. et al. Immunity 45, 46–59 (2016).

    Article  CAS  Google Scholar 

  10. Zhao, H. et al. Cell Death Dis. 6 e1975 (2015).

    Article  CAS  Google Scholar 

  11. Zhang, S. Y. et al. Science 317, 1522–1527 (2007).

    Article  CAS  Google Scholar 

  12. Suh, H. S., Brosnan, C. F. & Lee, S. C. Curr. Top. Microbiol. Immunol. 336, 63–81 (2009).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jason W. Upton.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ragan, K., Upton, J. Host response: Neurons loosen the gRIP of death. Nat Microbiol 2, 17090 (2017). https://doi.org/10.1038/nmicrobiol.2017.90

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/nmicrobiol.2017.90

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing