News and Views

Host response: Cross-fit T cells battle Zika virus

Flaviviruses stimulate cross-reactive immune responses that may reduce or exacerbate manifestations of subsequent flavivirus infection. Recent work demonstrates that cross-reactive T cells protect against Zika in HLA transgenic mice, a key step in the development of safe and effective vaccines.

  • Subscribe to Nature Microbiology for full access:

    $59

    Subscribe

Additional access options:

Already a subscriber?  Log in  now or  Register  for online access.

References

  1. 1.

    F1000Res. (2015).

  2. 2.

    & J. Virol. 90, 4864–4875 (2016).

  3. 3.

    et al. Nat. Microbiol. 2, 17036 (2017).

  4. 4.

    et al. Cell Host Microbe 21, 35–46 (2017).

  5. 5.

    & Front. Immunol. 5, 93 (2014).

  6. 6.

    J. Clin. Invest. 113, 946–951 (2014).

  7. 7.

    J. Virol. 89, 6494–6505 (2015).

  8. 8.

    et al. J. Immunol. 182, 4865–4873 (2009).

  9. 9.

    et al. PLoS Pathog. 13, e1006184 (2017).

  10. 10.

    et al. Science 353, 1129–1132 (2016).

  11. 11.

    et al. Nature 536, 474–478 (2016).

  12. 12.

    et al. J. Immunol. 187, 4268–4279 (2011).

Download references

Author information

Affiliations

  1. Matthew Collins is with the Division of Infectious Diseases in the Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

    • Matthew Collins
  2. Aravinda de Silva is in the Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

    • Aravinda de Silva

Authors

  1. Search for Matthew Collins in:

  2. Search for Aravinda de Silva in:

Competing interests

A.d.S. has consulted on dengue vaccines for Takeda Vaccines, Glaxo Smith Kline and Merck Pharmaceuticals. A.d.S. is an inventor on patents related to dengue vaccines.

Corresponding author

Correspondence to Aravinda de Silva.