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Viral pathogenesis: Dengue virus takes on cGAS

The sensor cyclic GMP–AMP synthase (cGAS) is well known to recognize viral DNA. In this issue of Nature Microbiology, infection by dengue virus (DENV), which has an RNA genome, is shown to induce mitochondrial DNA release into the cytosol, leading to cGAS activation. In turn, DENV targets cGAS to evade antiviral immunity.

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Figure 1: Dengue virus elicits and blocks cGAS-mediated immunity.

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Correspondence to Michaela U. Gack.

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van Gent, M., Gack, M. Viral pathogenesis: Dengue virus takes on cGAS. Nat Microbiol 2, 17050 (2017). https://doi.org/10.1038/nmicrobiol.2017.50

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