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Roadmap for antibiotic discovery

Nature Microbiology volume 1, Article number: 16083 (2016) Cite this article

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There are no antibiotic candidates simply waiting to be brought to market. Overcoming the scientific barriers to innovation will require research and coordination beyond anything that exists in academia, industry or government. We discuss a plan to accelerate the discovery of antibiotics and their transition into the clinic.

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Figure 1: Discovery of novel antibiotic classes (groups of drugs with similar chemical structures) has declined since the mid-twentieth century.

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Acknowledgements

We thank the antibiotic discovery working group, which included S. Brickner (SJ Brickner Consulting); K. Bush (Indiana University Bloomington); T. Dougherty (Harvard Medical School); Erwin (Erwin Consulting); D. Hooper (Massachusetts General Hospital); D. Hung (Broad Institute); Kwong (InnovaTID Pharmaceuticals); R. Lee (St Jude Children's Research Hospital); K. Lewis (Northeastern University); Miller (Entasis Therapeutics); S. Mobashery (University of Notre Dame); B. Mott (National Center for Advancing Translational Sciences, National Institutes of Health); D. Payne (GlaxoSmithKline); M. Riley (University of Massachusetts Amherst); Rubio (Spero Therapeutics); Silver (LL Silver Consulting); J. Silverman (VL32); J. Sutcliffe (Tetraphase Pharmaceuticals); Tomaras (BacterioScan); R. Tommasi (Entasis Therapeutics); and D. Zurawski (Walter Reed Army Institute of Research). In addition, we thank T. Schenkelberg (West Monument Consulting) for providing strategic advice. Although these individuals provided input on the roadmap, neither they nor their organizations necessarily endorse its findings or conclusions.

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  1. Carolyn K. Shore and Allan Coukell are at The Pew Charitable Trusts, 901 E St. NW, Washington, DC 20004, USA.,

    Carolyn K. Shore & Allan Coukell

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  1. Carolyn K. Shore
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  2. Allan Coukell
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Correspondence to Carolyn K. Shore or Allan Coukell.

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Shore, C., Coukell, A. Roadmap for antibiotic discovery. Nat Microbiol 1, 16083 (2016). https://doi.org/10.1038/nmicrobiol.2016.83

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