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Bacterial genomics: Microbial GWAS coming of age

A linear-mixed modelling genome-wide association approach for detecting genes and genetic variants underlying antibiotic resistance in bacterial pathogens heralds a new era for microbial genome-wide association studies.

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Figure 1: Genome-wide association studies (GWAS) are performed according to similar principles in humans (left) and bacteria (right) but controlling for the possible confounding effects of genomic relatedness (here shown using a phylogenetic tree) is particularly important in bacterial GWAS.


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Correspondence to Daniel Falush.

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Falush, D. Bacterial genomics: Microbial GWAS coming of age. Nat Microbiol 1, 16059 (2016).

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