Methylation of HIV RNA has been identified as a way to modulate export of viral transcripts, thereby impacting viral gene expression and particle production. Thus epitranscriptomics adds a new layer of complexity in viral gene expression regulation and also new opportunities for developing therapeutic strategies.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Meyer, K. D. & Jaffrey, S. R. Nature Rev. Mol. Cell Biol. 15, 313–326 (2014).
Fu, Y., Dominissini, D., Rechavi, G. & He, C. Nature Rev. Genet. 15, 293–306 (2014).
Machnicka, M. A. et al. Nucleic Acids Res. 41, D262–D267 (2013).
Wang, X. et al. Nature 505, 117–120 (2014).
Zhao, X. et al. Cell Res. 24, 1403–1419 (2014).
Zhu, T. et al. Cell Res. 24, 1493–1496 (2014).
Liu, N. et al. Nature 518, 560–564 (2015).
Wang, X. et al. Cell 161, 1388–1399 (2015).
Lee, M., Kim, B. & Kim, V. N. Cell 158, 980–987 (2014).
Lichinchi, G. et al. Nature Microbiol. 1, 16011 (2016).
Kane, S. E. & Beemon, K. Mol. Cell. Biol. 5, 2298–2306 (1985).
Krug, R. M., Morgan, M. A. & Shatkin, A. J. J. Virol. 20, 45–53 (1976).
Finkel, D. & Groner, Y. Virology 131, 409–425 (1983).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ciuffi, A. Viral cell biology: HIV RNA gets methylated. Nat Microbiol 1, 16037 (2016). https://doi.org/10.1038/nmicrobiol.2016.37
Published:
DOI: https://doi.org/10.1038/nmicrobiol.2016.37