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Viral cell biology: HIV RNA gets methylated

Methylation of HIV RNA has been identified as a way to modulate export of viral transcripts, thereby impacting viral gene expression and particle production. Thus epitranscriptomics adds a new layer of complexity in viral gene expression regulation and also new opportunities for developing therapeutic strategies.

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Figure 1: The multiple layers of regulation for viral gene expression.

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Correspondence to Angela Ciuffi.

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Ciuffi, A. Viral cell biology: HIV RNA gets methylated. Nat Microbiol 1, 16037 (2016). https://doi.org/10.1038/nmicrobiol.2016.37

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  • DOI: https://doi.org/10.1038/nmicrobiol.2016.37

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