Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Role of gut flora after bone marrow transplantation

The intestinal microbiota and its interactions with host immunity have been intensely studied in many disease states. This knowledge could ultimately modify clinical management of allogeneic haematopoietic stem cell transplantation, which is accompanied by dramatic immunological and microbiota perturbations.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Clinical intervention on the gut microbiota.


  1. Jenq, R. R. et al. Biol. Blood Marrow Transplant. 21, 1373–1383 (2015).

    Article  Google Scholar 

  2. Taur, Y. et al. Clin. Infect. Dis. 55, 905–914 (2012).

    Article  CAS  Google Scholar 

  3. Taur, Y. et al. Blood 124, 1174–1182 (2014).

    Article  CAS  Google Scholar 

  4. Holler, E. et al. Biol. Blood Marrow Transplant. 20, 640–645 (2014).

    Article  Google Scholar 

  5. Taur, Y. Autologous fecal microbiota transplantation (auto-FMT) for prophylaxis of Clostridium difficile infection in recipients of allogeneic hematopoietic stem cell transplantation. Clinical trial NCT02269150 (2014);

  6. Gerbitz, A. et al. Blood 103, 4365–4367 (2004).

    Article  CAS  Google Scholar 

  7. Jenq, R. R. et al. J. Exp. Med. 209, 903–911 (2012).

    Article  CAS  Google Scholar 

  8. van Bekkum, D. W., Roodenburg, J., Heidt, P. J. & van der Waaij, D. J. Natl Cancer Inst. 52, 401–404 (1974).

    Article  CAS  Google Scholar 

  9. Storb, R. et al. N. Engl. J. Med. 308, 302–307 (1983).

    Article  CAS  Google Scholar 

  10. Beelen, D. W. et al. Blood 93, 3267–3275 (1999).

    CAS  PubMed  Google Scholar 

  11. Vossen, J. M. et al. PLoS ONE 9, e105706 (2014).

    Article  Google Scholar 

  12. Weber, D. et al. Bone Marrow Transplant. (2016).

  13. Weber, D. et al. Blood 126, 1723–1728 (2015).

    Article  CAS  Google Scholar 

  14. Mathewson, N. D. et al. Nature Immunol. (2016).

  15. Buffie, C. G. et al. Nature 517, 205–8 (2014).

    Article  Google Scholar 

  16. Zitvogel, L. et al. Sci. Transl. Med. 7, 271ps1 (2015).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Marcel R. M. van den Brink.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Peled, J., Jenq, R., Holler, E. et al. Role of gut flora after bone marrow transplantation. Nat Microbiol 1, 16036 (2016).

Download citation

  • Published:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing