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Role of gut flora after bone marrow transplantation

Nature Microbiology volume 1, Article number: 16036 (2016) Cite this article

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The intestinal microbiota and its interactions with host immunity have been intensely studied in many disease states. This knowledge could ultimately modify clinical management of allogeneic haematopoietic stem cell transplantation, which is accompanied by dramatic immunological and microbiota perturbations.

In recent years, the importance of the microbiota in many aspects of health and disease has become increasingly clear, and it is no surprise that the clinicaltrials.gov registry includes over two-thousand human studies related to microbiota. In our opinion, understanding the impact that gut microbiota have on patients, and the alterations that physicians could make accordingly to therapeutic approaches, will improve the clinical outcomes of complex human diseases. Using allogeneic haematopoietic stem cell transplantation (allo-HSCT) as an example, we will illustrate how the study of intestinal microbiota can inform clinical care and research.

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Figure 1: Clinical intervention on the gut microbiota.

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Authors and Affiliations

  1. Department of Medicine Memorial Sloan Kettering Cancer Center, Jonathan U. Peled, Robert R. Jenq and Marcel R. M. van den Brink are at the Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA.,

    Jonathan U. Peled, Robert R. Jenq & Marcel R. M. van den Brink

  2. Ernst Holler is in the Department of Hematology and Oncology Internal Medicine III, Internal Medicine III, University Medical Center, Regensburg D-93042, Germany.,

    Ernst Holler

Authors
  1. Jonathan U. Peled
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  2. Robert R. Jenq
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  3. Ernst Holler
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  4. Marcel R. M. van den Brink
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Correspondence to Marcel R. M. van den Brink.

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Peled, J., Jenq, R., Holler, E. et al. Role of gut flora after bone marrow transplantation. Nat Microbiol 1, 16036 (2016). https://doi.org/10.1038/nmicrobiol.2016.36

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