Bacterial evolution: Resistance is a numbers game

Plasmids are well known for spreading antibiotic-resistance genes between bacterial strains. Recent experiments show that they can also act as catalysts for evolutionary innovation, promoting rapid evolution of novel antibiotic resistance.

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Figure 1: Comparing the adaptive potential of a resistance gene carried on the chromosome, on a multicopy plasmid and, hypothetically, in multiple copies on the chromosome.

References

  1. 1

    San Millan, A., Escudero, J. A., Gifford, D. R., Mazel, D. & MacLean, R. C. Nat. Ecol. Evol. 1, 0010 (2016).

    Article  Google Scholar 

  2. 2

    Hendrickson, H., Slechta, E. S., Bergthorsson, U., Andersson, D. I. & Roth, J. R. Proc. Natl Acad. Sci. USA 99, 2164–2169 (2002).

    CAS  Article  Google Scholar 

  3. 3

    Harrison, E. & Brockhurst, M. A. Trends Microbiol. 20, 262–267 (2012).

    CAS  Article  Google Scholar 

  4. 4

    Hall, J. P. J., Wood, A. J., Harrison, E. & Brockhurst, M. A. Proc. Natl Acad. Sci. USA 113, 8260–8265 (2016).

    CAS  Article  Google Scholar 

  5. 5

    Loftie-Eaton, W. et al. Mol. Biol. Evol. 33, 885–897 (2016).

    CAS  Article  Google Scholar 

  6. 6

    San Millan, A., Toll-Riera, M., Qi, Q. & MacLean, R. C. Nat. Commun. 6, 6845 (2015).

    CAS  Article  Google Scholar 

  7. 7

    Colegrave, N. & Collins, S. Heredity 100, 464–470 (2008).

    CAS  Article  Google Scholar 

  8. 8

    de Toro, M., Garcilláon-Barcia, M. P. & De La Cruz, F. Microbiol. Spectr. http://doi.org/br6q (2014).

  9. 9

    Salverda, M. L. M., De Visser, J. A. G. M. & Barlow, M. FEMS Microbiol. Rev. 34, 1015–1036 (2010).

    CAS  Article  Google Scholar 

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Correspondence to Ellie Harrison.

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Hall, J., Harrison, E. Bacterial evolution: Resistance is a numbers game. Nat Microbiol 1, 16235 (2016). https://doi.org/10.1038/nmicrobiol.2016.235

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