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Faecal microbiota transplantation is promising but not a panacea

Faecal microbiota transplantation has proved efficacious for diseases such as recurrent Clostridium difficile infection via restoration of gut microbial ecology and bile acid content. However, despite its adoption by mainstream medicine, misuse of this technology in clinical or domestic settings warrants caution.

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References

  1. 1

    Lessa, F. C. et al. N. Engl. J. Med. 372, 825–834 (2015).

    CAS  Article  Google Scholar 

  2. 2

    Borody, T. J. & Khoruts, A. Nature Rev. Gastroenterol. Hepatol. 9, 88–96 (2012).

    CAS  Article  Google Scholar 

  3. 3

    Hamilton, M. J., Weingarden, A. R., Sadowsky, M. J. & Khoruts, A. Am. J. Gastroenterol. 107, 761–767 (2012).

    Article  Google Scholar 

  4. 4

    Youngster, I. et al. J. Am. Med. Assoc. 312, 1772–1778 (2014).

    CAS  Article  Google Scholar 

  5. 5

    Bakken, J. S. et al. Clin. Gastroenterol. Hepatol. 9, 1044–1049 (2011).

    Article  Google Scholar 

  6. 6

    Floch, M. H. J. Clin. Gastroenterol. 44, 529–530 (2010).

    Article  Google Scholar 

  7. 7

    Weingarden, A. R. et al. Am. J. Physiol. Gastrointest. Liver Physiol. 306 G310–G319 (2014).

    CAS  Article  Google Scholar 

  8. 8

    Weingarden, A. R.et al. PLoS ONE 11, e0147210 (2016).

  9. 9

    Weingarden, A. R. et al. J. Clin. Gastroenterol. http://doi.org/bcgf (2015).

    Google Scholar 

  10. 10

    Ridaura, V. K. et al. Science 341, 1241214 (2013).

    Article  Google Scholar 

  11. 11

    Smith, M. I. et al. Science 339, 548–554 (2013).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Michael J. Sadowsky.

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Sadowsky, M., Khoruts, A. Faecal microbiota transplantation is promising but not a panacea. Nat Microbiol 1, 16015 (2016). https://doi.org/10.1038/nmicrobiol.2016.15

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