Parasite access to the central nervous system is a severe complication of infection. Toxoplasma gondii can achieve this by directly infecting, replicating in and lysing blood–brain barrier endothelial cells.
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References
Konradt, C. et al. Nature Microbiol. 1, 16001 (2016).
Lambert, H. & Barragan, A. Cell. Microbiol. 12, 292–300 (2010).
Butler, N. J., Furtado, J. M., Winthrop, K. L. & Smith, J. R. Clin. Exp. Ophthalmol. 41, 95–108 (2013).
Harker, K. S., Ueno, N. & Lodoen, M. B. Parasite Immunol. 37, 141–149 (2015).
Ueno, N. et al. Immunol. Cell Biol. 93, 508–513 (2015).
Antonio, B., Brossier, F. & Sibley, L. D. Cell. Microbiol. 7, 561–568 (2005).
Fox, B. A. & Bzik, D. J. Nature 415, 926–929 (2002).
Harker, K. S. et al. mBio 5, e01111–e01113 (2014).
Sofroniew, M. V. Nature Rev. Neurosci. 16, 249–263 (2015).
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Krishnan, A., Soldati-Favre, D. Parasite pathogenesis: Breaching the wall for brain access. Nat Microbiol 1, 16014 (2016). https://doi.org/10.1038/nmicrobiol.2016.14
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DOI: https://doi.org/10.1038/nmicrobiol.2016.14