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Host response: A trigger for neurodegeneration?

A new study provides clues to the physiological function of amyloid-β (Aβ), the plaque-forming peptide associated with Alzheimer's disease and finds a role for Aβ in fighting infection in the brain, by entangling pathogens in a web of amyloid fibrils. These data add to a growing appreciation of the role of microorganisms in neurodegenerative disease.

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Figure 1: A schematic of the hypothetical chain of events by which brain infection may lead to pathological amyloid-β peptide (Aβ) plaque formation in the brain.


  1. Cryan, J. F. & Dinan, T. G. Nature Rev. Neurosci. 13, 701–712 (2012).

    Article  CAS  Google Scholar 

  2. Soscia, S. J. et al. PLoS ONE 5, e9505 (2010).

    Article  Google Scholar 

  3. Lim, S. L., Rodriguez-Ortiz, C. J. & Kitazawa, M. Microbes Infect. 17, 549–556 (2015).

    Article  CAS  Google Scholar 

  4. Maheshwari, P. & Eslick, G. D. J. Alzheimers Dis. 43, 957–966 (2015).

    Article  Google Scholar 

  5. Sampson, T. R. & Mazmanian, S. K. Cell Host Microbe 17, 565–576 (2015).

    Article  CAS  Google Scholar 

  6. Dinan, T. G., Stilling, R. M., Stanton, C. & Cryan, J. F. J. Psychiatr. Res. 63, 1–9 (2015).

    Article  Google Scholar 

  7. Stilling, R. M., Dinan, T. G. & Cryan, J. F. Genes Brain Behav. 13, 69–86 (2014).

    Article  CAS  Google Scholar 

  8. Itzhaki, R. F. et al. J. Alzheimers Dis. 51, 979–984 (2016).

    Article  Google Scholar 

  9. Kumar, D. K. V. et al. Sci. Transl. Med. 8, 340ra72 (2016).

    Article  Google Scholar 

  10. Riviere, G. R., Riviere, K. H. & Smith, K. S. Oral Microbiol. Immunol. 17, 113–118 (2002).

    Article  CAS  Google Scholar 

  11. MacDonald, A. B. Med. Hypotheses 68, 1059–1064 (2007).

    Article  Google Scholar 

  12. Miklossy, J. J. Neuroinflammation 8, 90 (2011).

    Article  Google Scholar 

  13. Harach T. et al. Preprint at (2015).

  14. Jung, B.-K. et al. PLoS ONE 7, e33312 (2012).

    Article  CAS  Google Scholar 

  15. Kusbeci, O. Y., Miman, O., Yaman, M., Aktepe, O. C. & Yazar, S. Alzheimer Dis. Assoc. Disord. 25, 1–3 (2011).

    Article  Google Scholar 

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Correspondence to John F. Cryan.

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Stilling, R., Cryan, J. Host response: A trigger for neurodegeneration?. Nat Microbiol 1, 16129 (2016).

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