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Bacterial evolution: Making a host-adapted bacterium

Genomic analysis of Salmonella Enteritidis isolates taken from a single individual with a chronic and relapsing infection reveals how these bacteria have adapted to their host surroundings. Increased within-host fitness comes at the expense of ancillary traits such as virulence.

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Figure 1: Within-host evolution of S. Enteritidis in an immunocompromised human host.


  1. 1

    Zaneveld, J. et al. Curr. Opin. Chem. Biol. 12, 109–114 (2008).

    CAS  Article  Google Scholar 

  2. 2

    Smith, P. A. & Romesberg, F. E. Nature Chem. Biol. 3, 549–556 (2007).

    CAS  Article  Google Scholar 

  3. 3

    Rasko, D. A. & Sperandio, V. Nature Rev. Drug Discov. 9, 117–128 (2010).

    CAS  Article  Google Scholar 

  4. 4

    Alizon, S., Luciani, F. & Regoes, R. R. Trends Microbiol. 19, 24–32 (2011).

    CAS  Article  Google Scholar 

  5. 5

    Klemm, E. J. et al. Nature Microbiol. 1, 15023 (2016).

    CAS  Article  Google Scholar 

  6. 6

    McClelland, M. et al. Nature Genet. 36, 1268–1274 (2004).

    CAS  Article  Google Scholar 

  7. 7

    MacLennan, C. et al. J. Infect. Dis. 190, 1755–1757 (2004).

    CAS  Article  Google Scholar 

  8. 8

    Feliziani, S. et al. PLoS Genet. 10, e1004651 (2014).

    Article  Google Scholar 

  9. 9

    Martina, P. et al. Int. J. Med. Microbiol. 304, 1182–1191 (2014).

    CAS  Article  Google Scholar 

  10. 10

    Nuccio, S.-P. & Bäumler, A. J. mBio 5 e00929–14 (2014).

    Article  Google Scholar 

  11. 11

    Dougan, G. & Baker, S. Annu. Rev. Microbiol. 68, 317–336 (2014).

    CAS  Article  Google Scholar 

  12. 12

    Zdziarski, J. et al. PLoS Pathog. 6, e1001078 (2010).

    Article  Google Scholar 

  13. 13

    Lieberman, T. D. et al. Nature Genet. 46, 82–87 (2014).

    CAS  Article  Google Scholar 

  14. 14

    Workentine, M. L. et al. PLoS ONE 8, e60225 (2013).

    CAS  Article  Google Scholar 

  15. 15

    Gerrish, P. J. & Lenski, R. E. Genetica 102–103 127–144 (1998).

    Article  Google Scholar 

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Correspondence to Brian K. Coombes.

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Coombes, B. Bacterial evolution: Making a host-adapted bacterium. Nat Microbiol 1, 16010 (2016).

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