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Bacterial evolution: Making a host-adapted bacterium

Nature Microbiology volume 1, Article number: 16010 (2016) Cite this article

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Genomic analysis of Salmonella Enteritidis isolates taken from a single individual with a chronic and relapsing infection reveals how these bacteria have adapted to their host surroundings. Increased within-host fitness comes at the expense of ancillary traits such as virulence.

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Figure 1: Within-host evolution of S. Enteritidis in an immunocompromised human host.

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Affiliations

  1. Brian K. Coombes is the Canada Research Chair in Infectious Disease Pathogenesis at the Michael G. DeGroote Institute for Infectious Disease Research and the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada.

    Brian K. Coombes

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  1. Brian K. Coombes
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Correspondence to Brian K. Coombes.

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Coombes, B. Bacterial evolution: Making a host-adapted bacterium. Nat Microbiol 1, 16010 (2016). https://doi.org/10.1038/nmicrobiol.2016.10

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