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Bacterial evolution: Making a host-adapted bacterium

Genomic analysis of Salmonella Enteritidis isolates taken from a single individual with a chronic and relapsing infection reveals how these bacteria have adapted to their host surroundings. Increased within-host fitness comes at the expense of ancillary traits such as virulence.

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Figure 1: Within-host evolution of S. Enteritidis in an immunocompromised human host.

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Correspondence to Brian K. Coombes.

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Coombes, B. Bacterial evolution: Making a host-adapted bacterium. Nat Microbiol 1, 16010 (2016). https://doi.org/10.1038/nmicrobiol.2016.10

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