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Viral infection: A key host receptor for AAV

A transmembrane protein receptor that is critical for adeno-associated virus infection has been identified through an unbiased, genome-wide screen. Its role in viral entry could potentially be harnessed to develop enhanced gene therapy vectors and better animal models of human disease.

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Figure 1: The role of AAVR in AAV cellular entry.


  1. Grove, J. & Marsh, M. J. Cell Biol. 195, 1071–1082 (2011).

    Article  CAS  Google Scholar 

  2. Nonnenmacher, M. & Weber, T. Gene Ther. 19, 649–658 (2012).

    Article  CAS  Google Scholar 

  3. Qing, K. et al. Nature Med. 5, 71–77 (1999).

    Article  CAS  Google Scholar 

  4. Kashiwakura, Y. et al. J. Virol. 79, 609–614 (2005).

    Article  CAS  Google Scholar 

  5. Ling, C. et al. Hum. Gene Ther. 21, 1741–1747 (2010).

    Article  CAS  Google Scholar 

  6. Pillay, S. et al. Nature (2016).

  7. Santiago-Ortiz, J. & Ojala, D. S. et al. Gene Ther. 22, 934–946 (2015).

    Article  CAS  Google Scholar 

  8. Zinn, E. et al. Cell Rep. 12, 1056–1068 (2015).

    Article  CAS  Google Scholar 

  9. Poon, M. W., Tsang, W. H., Waye, M. M. & Chan, S. O. Histol. Histopathol. 26, 953–963 (2011).

    CAS  PubMed  Google Scholar 

  10. Hawrylycz, M. J. et al. Nature 489, 391–399 (2012).

    Article  CAS  Google Scholar 

  11. Kotterman, M. A. & Schaffer, D. V. Nature Rev. Genet. 15, 445–451 (2014).

    Article  CAS  Google Scholar 

  12. Ahronian, L. G. & Lewis, B. C. Cold Spring Harb. Protoc. 2014, 1128–1135 (2014).

    PubMed  Google Scholar 

Download references

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Correspondence to David V. Schaffer.

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Sun, S., Schaffer, D. Viral infection: A key host receptor for AAV. Nat Microbiol 1, 15027 (2016).

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