News & Views | Published:

Lighting up neural networks using a new generation of genetically encoded calcium sensors

Nature Methods volume 6, pages 871872 (2009) | Download Citation

Subjects

Abstract

Two improved genetically encoded calcium indicators—based on structure-guided sensor design or on precise subcellular targeting to presynaptic boutons—allow single spikes to be detected in genetically defined populations of neurons and synapses in vivo.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , et al. Nat. Methods 6, 875–881 (2009).

  2. 2.

    , , & Nat. Methods 6, 883–889 (2009).

  3. 3.

    & Nature 461, 930–939 (2009).

  4. 4.

    , , & Proc. Natl. Acad. Sci. USA 100, 7319–7324 (2003).

  5. 5.

    et al. Neuron 53, 789–803 (2007).

  6. 6.

    , , & Nature 385, 161–165 (1997).

  7. 7.

    & Chem. Rev. 108, 1550–1564 (2008).

  8. 8.

    et al. Nat. Methods 5, 805–811 (2008).

  9. 9.

    et al. Nat. Methods 5, 797–804 (2008).

  10. 10.

    , & Nat. Methods 6, 891–896 (2009).

  11. 11.

    et al. J. Neurosci. 28, 7399–7411 (2008).

  12. 12.

    et al. J. Biol. Chem. 284, 6455–6464 (2009).

  13. 13.

    , & Nature 394, 192–195 (1998).

Download references

Author information

Affiliations

  1. Christian D. Wilms and Michael Häusser are at the Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.

    • Christian D Wilms
    •  & Michael Häusser

Authors

  1. Search for Christian D Wilms in:

  2. Search for Michael Häusser in:

Corresponding author

Correspondence to Michael Häusser.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nmeth1209-871

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing