Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Pacing lightly: optogenetics gets to the heart

Transfer of the light-activated cation channel channelrhodopsin-2 gene enables optical control of heart muscle membrane potential.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Optogenetic control of heart muscle.

References

  1. Bruegmann, T. et al. Nat. Methods 7, 897–900 (2010).

    Article  CAS  Google Scholar 

  2. Gurney, A.M., Charnet, P., Pye, J.M. & Nargeot, J. Nature 341, 65–68 (1989).

    Article  CAS  Google Scholar 

  3. Jenkins, M.W. et al. Nat. Photonics 4, 623–626 (2010).

    Article  CAS  Google Scholar 

  4. Boyden, E.S., Zhang, F., Bamberg, E., Nagel, G. & Deisseroth, K. Nat. Neurosci. 8, 1263–1268 (2005).

    Article  CAS  Google Scholar 

  5. Chang, M.G. et al. Circ. Res. 105, 1062–1071 (2009).

    Article  CAS  Google Scholar 

  6. Xie, Y., Sato, D., Garfinkel, A., Qu, Z. & Weiss, J.N. Biophys. J. 99, 1408–1415 (2010).

    Article  CAS  Google Scholar 

  7. Adeyemi, A.A., Barakat, N. & Darcie, T.E. Opt. Express 17, 1831–1843 (2009).

    Article  Google Scholar 

  8. Roell, W. et al. Nature 450, 819–824 (2007).

    Article  CAS  Google Scholar 

  9. Zhang, F. et al. Nature 446, 633–639 (2007).

    Article  CAS  Google Scholar 

  10. Chow, B.Y. et al. Nature 463, 98–102 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Björn C Knollmann.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Knollmann, B. Pacing lightly: optogenetics gets to the heart. Nat Methods 7, 889–891 (2010). https://doi.org/10.1038/nmeth1110-889

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth1110-889

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing