News & Views | Published:

You too can play with an edge

Nature Methods volume 6, pages 797798 (2009) | Download Citation

Abstract

Strategies for the systematic isolation of alleles that selectively disrupt only one or a few interactions of the encoded protein will aid in the dissection of gene function.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Nat. Methods 6, 843–849 (2009).

  2. 2.

    & Nat. Methods 6, 813–816 (2009).

  3. 3.

    , , , & Annu. Rev. Genet. advance online publication, doi:10.1146/annurev.genet.39.073003.114751 (27 August 2009).

  4. 4.

    , & Proc. Natl. Acad. Sci. USA 93, 13908–13913 (1996).

  5. 5.

    , & Nat. Struct. Biol. 2, 28–35 (1995).

  6. 6.

    , & Genetics 132, 337–350 (1992).

  7. 7.

    et al. Science 303, 808–813 (2004).

Download references

Author information

Affiliations

  1. Michael Costanzo, Anastasia Baryshnikova, Corey Nislow, Brenda Andrews and Charles Boone are at the Banting and Best Department of Medical Research and Department of Molecular Genetics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada.

    • Michael Costanzo
    • , Anastasia Baryshnikova
    • , Corey Nislow
    • , Brenda Andrews
    •  & Charles Boone

Authors

  1. Search for Michael Costanzo in:

  2. Search for Anastasia Baryshnikova in:

  3. Search for Corey Nislow in:

  4. Search for Brenda Andrews in:

  5. Search for Charles Boone in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nmeth1109-797

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing