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Enrichment of super-sized resequencing targets from the human genome

Methods relying on dense arrays of synthetic oligodeoxynucleotides to target specific subsets of the human genome may enable routine resequencing of all human exons or multi-megabase-pair chromosomal regions.

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Figure 1: Two ways to use high-density arrays of custom-synthesized oligodeoxynucleotides to target subsets of the human genome.

Kim Caesar


  1. Porreca, J.G. et al. Nat. Methods 4, 931–936 (2007).

    Article  CAS  Google Scholar 

  2. Okou, T.D. et al. Nat. Methods 4, 907–909 (2007).

    Article  CAS  Google Scholar 

  3. Albert, T.J. et al. Nat. Methods 4, 903–905 (2007).

    Article  CAS  Google Scholar 

  4. Shendure, J. et al. Nat. Rev. Genet. 5, 335–344 (2004).

    Article  CAS  Google Scholar 

  5. Nilsson, M. et al. Science 265, 2085–2088 (1994).

    Article  CAS  Google Scholar 

  6. Hardenbol, P. et al. Nat. Biotechnol. 21, 673–678 (2003).

    Article  CAS  Google Scholar 

  7. Bashiardes, S. et al. Nat. Methods 2, 63–69 (2005).

    Article  CAS  Google Scholar 

  8. Guo, Z. et al. Proc. Natl. Acad. Sci. USA 103, 6964–6969 (2006).

    Article  CAS  Google Scholar 

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Olson, M. Enrichment of super-sized resequencing targets from the human genome. Nat Methods 4, 891–892 (2007).

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