Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Enrichment of super-sized resequencing targets from the human genome

Methods relying on dense arrays of synthetic oligodeoxynucleotides to target specific subsets of the human genome may enable routine resequencing of all human exons or multi-megabase-pair chromosomal regions.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Two ways to use high-density arrays of custom-synthesized oligodeoxynucleotides to target subsets of the human genome.

Kim Caesar

References

  1. Porreca, J.G. et al. Nat. Methods 4, 931–936 (2007).

    Article  CAS  Google Scholar 

  2. Okou, T.D. et al. Nat. Methods 4, 907–909 (2007).

    Article  CAS  Google Scholar 

  3. Albert, T.J. et al. Nat. Methods 4, 903–905 (2007).

    Article  CAS  Google Scholar 

  4. Shendure, J. et al. Nat. Rev. Genet. 5, 335–344 (2004).

    Article  CAS  Google Scholar 

  5. Nilsson, M. et al. Science 265, 2085–2088 (1994).

    Article  CAS  Google Scholar 

  6. Hardenbol, P. et al. Nat. Biotechnol. 21, 673–678 (2003).

    Article  CAS  Google Scholar 

  7. Bashiardes, S. et al. Nat. Methods 2, 63–69 (2005).

    Article  CAS  Google Scholar 

  8. Guo, Z. et al. Proc. Natl. Acad. Sci. USA 103, 6964–6969 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Olson, M. Enrichment of super-sized resequencing targets from the human genome. Nat Methods 4, 891–892 (2007). https://doi.org/10.1038/nmeth1107-891

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth1107-891

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing