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Double display


By combining two display sites on a single phage, researchers at the M.D. Anderson Cancer Center have created a way to easily conjugate a targeting peptide to a variety of functional moieties, making the bifunctional phage a coupling tool with many promising applications.

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  1. Giordano, R.J. et al. Biopanning and rapid analysis of selective interactive ligands. Nat. Med. 7, 1249–1253 (2001).

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  3. Chen, L. et al. Design and validation of a bifunctional ligand display system for receptor targeting. Chem. Biol. 11, 1081–1091 (2004).

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Kiermer, V. Double display. Nat Methods 1, 8–9 (2004).

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