Arrays of microposts of different heights generate substrates with different flexibility, on which cells can be grown.
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References
Fu, J. et al. Nat. Methods 7, 733–736 (2010).
Engler, A.J., Sen, S., Sweeney, H.L. & Discher, D.E. Cell 126, 677–689 (2006).
Saha, K. et al. Biophys. J. 95, 4426–4438 (2008).
Serena, E. et al. Integrative Biol. 2, 193–201 (2010).
Kong, H.J., Polte, T.R., Alsberg, E. & Mooney, D.J. Proc. Natl. Acad. Sci. USA 102, 4300–4305 (2005).
Pelham, R.J. & Wang, Y.L. Proc. Natl. Acad. Sci. USA 94, 13661–13665 (1997).
Zemel, A., Rehfeldt, F., Brown, A.E.X., Discher, D.E. & Safran, S.A. Nat. Phys. 6, 468–473 (2010).
Saez, A., Buguin, A., Silberzan, P. & Ladoux, B. Biophys. J. 89, L52–L54 (2005).
Discher, D.E., Mooney, D.J. & Zandstra, P.W. Science 324, 1673–1677 (2009).
Engler, A.J. et al. Biophys. J. 86, 617–628 (2004).
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Buxboim, A., Discher, D. Stem cells feel the difference. Nat Methods 7, 695–697 (2010). https://doi.org/10.1038/nmeth0910-695
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DOI: https://doi.org/10.1038/nmeth0910-695
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