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Tethered together

Nature Methods volume 6, pages 630–631 (2009)Cite this article

Researchers describe a genetic approach to identify the native components responsible for forming molecular transport junctions between the mitochondria and the endoplasmic reticulum.

Eukaryotic cells evolved to have specialized compartments—organelles—which perform different functions, thus optimizing the specificity and efficiency of biochemical reactions. Concomitant to this compartmentalization, routes for communication and molecular transport between organelles also had to evolve. As one example, lipids that are synthesized in the endoplasmic reticulum (ER) are exported via vesicles that ship the lipids to other organelles. However, no mitochondrial ports are found on these vesicular shipping routes. It is not well understood how such necessary components are transported from the ER to the mitochondria.

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References

  1. Kornmann, B. et al. An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 325, 477–481 (2009).

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Authors
  1. Allison Doerr
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Doerr, A. Tethered together. Nat Methods 6, 630–631 (2009). https://doi.org/10.1038/nmeth0909-630a

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  • DOI: https://doi.org/10.1038/nmeth0909-630a

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