Fishing at the cellular level

A platform for automated screening of zebrafish larvae in high throughput should allow detection of phenotypic changes in single cells.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: A high-throughput platform for zebrafish screening.

References

  1. 1

    Pardo-Martin, C. et al. Nat. Methods 7, 634–636 (2010).

    CAS  Article  Google Scholar 

  2. 2

    Zon, L.I. & Peterson, R.T. Nat. Rev. Drug Discov. 4, 35–44 (2005).

    CAS  Article  Google Scholar 

  3. 3

    Kokel, D. et al. Nat. Chem. Biol. 6, 231–237 (2010).

    CAS  Article  Google Scholar 

  4. 4

    Rihel, J. et al. Science 327, 348–351 (2010).

    CAS  Article  Google Scholar 

  5. 5

    Tran, T.C. et al. Cancer Res 67, 11386–11392 (2007).

    CAS  Article  Google Scholar 

  6. 6

    Fricke, C., Lee, J.S., Geiger-Rudolph, S., Bonhoeffer, F. & Chien, C.B. Science 292, 507–510 (2001).

    CAS  Article  Google Scholar 

  7. 7

    Kozlowski, D.J. & Weinberg, E.S. Methods Mol. Biol. 135, 349–355 (2000).

    CAS  PubMed  Google Scholar 

  8. 8

    Esengil, H., Chang, V., Mich, J.K., & Chen, J.K Nat. Chem. Biol. 3, 154–155 (2007).

    CAS  Article  Google Scholar 

  9. 9

    Sinha, D.K. et al. Zebrafish 7, 199–204 (2010).

    CAS  Article  Google Scholar 

  10. 10

    Hatta, K., Tsujii, H. & Omura, T. Nat. Protoc. 1, 960–967 (2006).

    CAS  Article  Google Scholar 

  11. 11

    Aramaki, S. & Hatta, K. Dev. Dyn. 235, 2192–2199 (2006).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Leonard I Zon.

Ethics declarations

Competing interests

L.I.Z. is a founder and stock holder of Fate, Inc. and a scientific advisor for Stemgent.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Tamplin, O., Zon, L. Fishing at the cellular level. Nat Methods 7, 600–601 (2010). https://doi.org/10.1038/nmeth0810-600

Download citation

Further reading

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing