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Hold me tightly LOV

Nature Methods volume 7, pages 595–596 (2010)Cite this article

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Mutations that increase the dynamic range of a photoswitchable protein may be used to improve other such photoswitches and increase their potential for allosteric control of protein activity in live cells.

The light-oxygen-voltage (LOV) protein domain has been recently used to control protein activity in living cells with light. In this issue of Nature Methods, Strickland et al. engineer important changes to improve the photophysical properties of this domain1.

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Figure 1: LOV domain–based photoswitches.

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Authors and Affiliations

  1. Klaus M. Hahn and Brian Kuhlman are at the University of North Carolina, Chapel Hill, North Carolina, USA.,

    Klaus M Hahn & Brian Kuhlman

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  1. Klaus M Hahn
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  2. Brian Kuhlman
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Correspondence to Klaus M Hahn or Brian Kuhlman.

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Hahn, K., Kuhlman, B. Hold me tightly LOV. Nat Methods 7, 595–596 (2010). https://doi.org/10.1038/nmeth0810-595

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