News & Views | Published:

Hold me tightly LOV

Nature Methods volume 7, pages 595596 (2010) | Download Citation

Mutations that increase the dynamic range of a photoswitchable protein may be used to improve other such photoswitches and increase their potential for allosteric control of protein activity in live cells.

  • Subscribe to Nature Methods for full access:

    $59

    Subscribe

Additional access options:

Already a subscriber?  Log in  now or  Register  for online access.

References

  1. 1.

    et al. Nat. Methods 7, 623–626 (2010).

  2. 2.

    & Annu. Rev. Biochem. 79, 413–444 (2010).

  3. 3.

    , , , & Nature 458 (7241), 1025–1029 (2009).

  4. 4.

    , , & Nature 461, 997–1001 (2009).

  5. 5.

    et al. Nature 461, 104–108 (2009).

  6. 6.

    et al. Dev. Cell 18, 226–236 (2010).

  7. 7.

    et al. Science 322, 438–442 (2008).

  8. 8.

    , & Proc. Natl. Acad. Sci. USA 105, 10709–10714 (2008).

  9. 9.

    , & , Nat. Chem. Biol. 4, 491–497 (2008).

  10. 10.

    et al. Biochemistry 46, 9310–9319 (2007).

  11. 11.

    & Nat. Chem. Biol. 5, 827–834 (2009).

Download references

Author information

Affiliations

  1. Klaus M. Hahn and Brian Kuhlman are at the University of North Carolina, Chapel Hill, North Carolina, USA.

    • Klaus M Hahn
    •  & Brian Kuhlman

Authors

  1. Search for Klaus M Hahn in:

  2. Search for Brian Kuhlman in:

Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Klaus M Hahn or Brian Kuhlman.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nmeth0810-595

Rights and permissions

To obtain permission to re-use content from this article visit RightsLink.