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MutationTaster evaluates disease-causing potential of sequence alterations

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  1. Wheeler, D.A. et al. Nature 452, 872–876 (2008).

    CAS  Article  Google Scholar 

  2. Hand, D.J. & Yu, K.M. Int. Stat. Rev. 69, 385–398 (2001).

    Google Scholar 

  3. Mi, H. et al. Nucleic Acids Res. 33, D284–D288 (2005).

    CAS  Article  Google Scholar 

  4. Ferrer-Costa, C. et al. Bioinformatics. 21, 3176–3178 (2005).

    CAS  Article  Google Scholar 

  5. Adzhubei, I.A. et al. Nat. Methods 7, 248–249 (2010).

    CAS  Article  Google Scholar 

  6. Bromberg, Y. & Rost, B. Nucleic Acids Res. 35, 3823–3835 (2007).

    CAS  Article  Google Scholar 

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This project was supported by the Deutsche Forschungsgemeinschaft via the NeuroCure Cluster of Excellence, Exc 257, and the Collaborative Research Center 665 TP C4. M.S. and D.S. are members of the German network for mitochondrial disorders (mitoNET, 01GM0862), funded by the German ministry of education and research (BMBF). We thank H. Peters for providing mutation data, M. Zhang and M. Reese for allowing us to integrate polyadq and NNSplice, E. Lüdeking for proofreading the manuscript, and all beta users whose valuable recommendations guided the development of MutationTaster.

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Correspondence to Dominik Seelow.

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Schwarz, J., Rödelsperger, C., Schuelke, M. et al. MutationTaster evaluates disease-causing potential of sequence alterations. Nat Methods 7, 575–576 (2010).

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