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ChIP-seq: welcome to the new frontier

Nature Methods volume 4, pages 613–614 (2007)Cite this article

Next-generation sequencing technology combines with chromatin immunoprecipitation to provide a genome-wide look at transcription-factor binding.

Next-generation sequencing technologies, capable of producing tens of millions of sequence reads during each instrument run, are quickly being applied in a myriad of creative ways to answer genome-wide questions. In this issue, Robertson and colleagues describe such an application, comparing chromatin immunoprecipitation (ChIP) of the Stat1 transcription factor using a next-generation sequencing platform and a conventional microarray-based platform1.

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Figure 1: Workflow of Chip-seq.

Katie Ris

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Authors and Affiliations

  1. Elaine R. Mardis is at the Washington University School of Medicine, St. Louis, Missouri 63108, USA. emardis@watson.wustl.edu,

    Elaine R Mardis

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  1. Elaine R Mardis
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The author declares no competing financial interests.

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Mardis, E. ChIP-seq: welcome to the new frontier. Nat Methods 4, 613–614 (2007). https://doi.org/10.1038/nmeth0807-613

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