Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

ChIP-seq: welcome to the new frontier

Next-generation sequencing technology combines with chromatin immunoprecipitation to provide a genome-wide look at transcription-factor binding.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Workflow of Chip-seq.

Katie Ris


  1. Robertson, G. et al. Nat. Methods 4, 651–657 (2007).

    Article  CAS  Google Scholar 

  2. Solomon, M.J., Larsen, P.L. & Varshavsky, A. Cell 53, 937–947 (1988).

    Article  CAS  Google Scholar 

  3. Ren, B. et al. Science 290, 2306–2309 (2000).

    Article  CAS  Google Scholar 

  4. Bentley, D.R. Curr. Opin. Genet. Dev. 16, 545–552 (2006).

    Article  CAS  Google Scholar 

  5. Brierley, M.M. & Fish, E.N. J. Interferon Cytokine Res. 25, 733–744 (2005).

    Article  CAS  Google Scholar 

  6. Schroder, K. et al. J. Leukoc. Biol. 75, 163–189 (2004).

    Article  CAS  Google Scholar 

  7. Johnson, D.S. et al. Science 316, 1497–1502 (2007).

    Article  CAS  Google Scholar 

  8. Barski, A. et al. Cell 129, 823–837 (2007).

    Article  CAS  Google Scholar 

  9. Mikkelsen, T.S. et al. Nature; published online 1 July 2007.

Download references

Author information

Authors and Affiliations


Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mardis, E. ChIP-seq: welcome to the new frontier. Nat Methods 4, 613–614 (2007).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing