Combating natural selection with 'antiviral Judo'

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Abstract

A method of screening for dominant inhibitors of viral growth could aid in combating RNA viruses by neutralizing their most powerful weapon—natural selection.

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References

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    Crowder, S. & Kirkegaard, K. Trans-dominant inhibition of RNA viral replication can slow growth of drug-resistant viruses. Nat. Genet. 37, 701–709 (2005).

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    Holland, J.J. et al. Virus mutation frequencies can be greatly underestimated by monoclonal antibody neutralization of virions. J. Virol. 63, 5030–5036 (1989).

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Evanko, D. Combating natural selection with 'antiviral Judo'. Nat Methods 2, 570 (2005) doi:10.1038/nmeth0805-570

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