Hastened to death

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Chemical-genetic selection in yeast identifies an inhibitor that targets a spindle-checkpoint kinase resulting in massive chromosome loss and cell death.

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    Dorer, R.K. et al. A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes. Curr. Biol. 15, 1070–1076 (2005).

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Rusk, N. Hastened to death. Nat Methods 2, 566–567 (2005) doi:10.1038/nmeth0805-566b

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