Home-grown HCV

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Abstract

Three teams of researchers have developed cell culture systems for the modeling of hepatitis C viral infection and the subsequent generation of infectious virus particles—an important breakthrough in the study of this disease.

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Figure 1: Huh7.5.1 cells, five days after infection with JH1-derived HCV.

References

  1. 1

    Wakita, T. et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat. Med. 11, 791–796 (2005).

  2. 2

    Zhong, J. et al. Robust hepatitis C virus infection in vitro. Proc. Natl. Acad. Sci. USA 102, 9294–9299 (2005).

  3. 3

    Lindenbach, B.D. et al. Complete replication of hepatitis C virus in cell culture. Science; published online 9 June, 2005.

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Eisenstein, M. Home-grown HCV. Nat Methods 2, 565 (2005) doi:10.1038/nmeth0805-565

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