The beginning of the end for microarrays?

Two complementary approaches, both using next-generation sequencing, have successfully tackled the scale and the complexity of mammalian transcriptomes, at once revealing unprecedented detail and allowing better quantification.

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Figure 1: One of the differences between RNA-Seq approaches is the protocol used to construct adaptor-flanked sequencing libraries from poly(A)+-enriched RNA.

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J.S. has patent applications filed in the field of next-generation sequencing.

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Shendure, J. The beginning of the end for microarrays?. Nat Methods 5, 585–587 (2008) doi:10.1038/nmeth0708-585

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