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ESCs keep their options open


Two powerful technologies enabled studies of chromatin that revealed features potentially responsible for the pluripotency of embryonic stem cells (ESCs).

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  1. 1

    Azuara, V. et al. Chromatin signatures of pluripotent cell lines. Nat. Cell Biol. 8, 532–538 (2006).

  2. 2

    Bernstein, B.E. et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315–326 (2006).

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Figure 1: Replication-timing analysis of ESCs, HSCs and T lymphocytes according to the extent of replication during G1, G2 and throughout S phase.