Encoding the unnatural

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Researchers evolved a ribosome that efficiently decodes quadruplet codons, thus opening up the possibility of genetically incorporating multiple unnatural amino acids into proteins.

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  1. 1

    Neumann, H. et al. Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome. Nature 464, 441–444 (2010a).

  2. 2

    Neumann, H. et al. De novo generation of mutually orthogonal aminoacyl-tRNA synthetase/tRNA pairs. J. Am. Chem. Soc. 132, 2142–2144 (2010b).

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Doerr, A. Encoding the unnatural. Nat Methods 7, 343 (2010) doi:10.1038/nmeth0510-343

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