Research Highlights | Published:

Knockouts with a touch of a zinc finger

Nature Methods volume 5, pages 378379 (2008) | Download Citation

Subjects

Abstract

Capitalizing on the imperfection of error-prone DNA repair, researchers generated knockout mammalian cell lines by targeting a nuclease to a gene of interest via a zinc-finger DNA-binding domain.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Targeted gene knockout in mammalian cells using engineered zinc-finger nucleases. Proc. Natl. Acad. Sci. USA, published online 21 March 2008.

Download references

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nmeth0508-378b

Authors

  1. Search for Irene Kaganman in:

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing