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Knockouts with a touch of a zinc finger

Nature Methods volume 5, pages 378–379 (2008)Cite this article

Abstract

Capitalizing on the imperfection of error-prone DNA repair, researchers generated knockout mammalian cell lines by targeting a nuclease to a gene of interest via a zinc-finger DNA-binding domain.

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References

  1. Santiago, Y. et al. Targeted gene knockout in mammalian cells using engineered zinc-finger nucleases. Proc. Natl. Acad. Sci. USA, published online 21 March 2008.

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Authors
  1. Irene Kaganman
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Cite this article

Kaganman, I. Knockouts with a touch of a zinc finger. Nat Methods 5, 378–379 (2008). https://doi.org/10.1038/nmeth0508-378b

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  • DOI: https://doi.org/10.1038/nmeth0508-378b

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