Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Large-scale genetic epistasis networks using RNAi

Nature Methods volume 8, pages 299–301 (2011)Cite this article

Subjects

Abstract

Pairwise quantitative genetic interactions are mapped by combinatorial RNA interference in metazoan cells.

Pairwise quantitative genetic interactions are mapped by combinatorial RNA interference in metazoan cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Workflow of a combinatorial RNAi screen for genetic interactions developed by Horn et al.2.

References

  1. Dixon, S.J. et al. Annu. Rev. Genet. 43, 601–625 (2009).

    Article  CAS  Google Scholar 

  2. Horn, T. et al. Nat. Methods 8, 341–346 (2011).

    Article  CAS  Google Scholar 

  3. Tong, A.H. et al. Science 294, 2364–2368 (2001).

    Article  CAS  Google Scholar 

  4. Tong, A.H. et al. Science 303, 808–813 (2004).

    Article  CAS  Google Scholar 

  5. Costanzo, M. et al. Science 327, 425–431 (2010).

    Article  CAS  Google Scholar 

  6. Lehner, B. et al. Nat. Genet. 38, 896–903 (2006).

    Article  CAS  Google Scholar 

  7. Luo, J. et al. Cell 137, 835–848 (2009).

    Article  CAS  Google Scholar 

  8. Casey, F.P. et al. Bioinformatics 24, 2733–2739 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Xiaoyue Wang and Kevin P. White are at the Institute for Genomics and Systems Biology and Department of Human Genetics, University of Chicago, Chicago, Illinois, USA.,

    Xiaoyue Wang & Kevin P White

Authors
  1. Xiaoyue Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kevin P White
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kevin P White.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, X., White, K. Large-scale genetic epistasis networks using RNAi. Nat Methods 8, 299–301 (2011). https://doi.org/10.1038/nmeth0411-299

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth0411-299

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing