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Dissecting signaling at the speed of light

Nature Methods volume 8, pages 284–285 (2011)Cite this article

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Researchers use light-activated photo-uncaging to dissect the elementary steps in protein kinase signaling networks in living human cells.

Protein kinase signaling pathways are complicated processes, which involve elementary steps that operate at different rates. To quantitatively understand kinase signaling pathways, the network connectivity and the kinetics of the individual steps must be thoroughly mapped.

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References

  1. Gautier, A. et al. Light-activated kinases enable temporal dissection of signaling networks in living cells. J. Am. Chem. Soc. 133, 2124–2127 (2011).

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  1. Allison Doerr
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Doerr, A. Dissecting signaling at the speed of light. Nat Methods 8, 284–285 (2011). https://doi.org/10.1038/nmeth0411-284b

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  • DOI: https://doi.org/10.1038/nmeth0411-284b

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