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A method and server for predicting damaging missense mutations

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Figure 1: PolyPhen-2 pipeline and prediction accuracy.


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We thank Y. Bromberg for help with the SNAP analysis. V.E.R. acknowledges support by the Russian Academy of Sciences Program in Molecular and Cellular Biology. This work was supported by the US National Institutes of Health (R01 GM078598 and in part by R01 MH084676).

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Correspondence to Shamil R Sunyaev.

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The authors declare no competing financial interests.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1–4, Supplementary Tables 1–2, Supplementary Methods (PDF 646 kb)

Supplementary Software

PolyPhen-2 standalone software for Linux/Mac OS X (ZIP 414 kb)

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Adzhubei, I., Schmidt, S., Peshkin, L. et al. A method and server for predicting damaging missense mutations. Nat Methods 7, 248–249 (2010).

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