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Putting long-range mapping in reach

Nature Methods volume 3, page 239 (2006) | Download Citation

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Abstract

A technique for performing PCR on extremely large DNA molecules offers researchers the ability to generate accurate multi-marker haplotypes for large numbers of patients—even with loci arrayed across entire human chromosomes.

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References

  1. 1.

    et al. Long-range polony haplotyping of individual human chromosome molecules. Nat. Genet. 38, 382–387 (2006).

  2. 2.

    & In situ localized amplification and contact replication of many individual DNA molecules. Nucleic Acids Res. 27, e34 (1999).

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About this article

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Published

DOI

https://doi.org/10.1038/nmeth0406-239

Authors

  1. Search for Michael Eisenstein in:

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