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Herpesviruses throw a curve ball: new insights into microRNA biogenesis and evolution

Nature Methods volume 2, pages 252254 (2005) | Download Citation

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Validation and comparison of previously unknown microRNA genes in related herpesviruses yielded several surprises, most notably in regard to viral evolution and microRNA biogenesis. An explosion of literature has recently appeared describing the identification and mechanism of action of microRNAs (miRNAs)—small RNA regulators of gene expression in plant and animal cells.

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Author information

Affiliations

  1. Joel R. Neilson and Phillip A. Sharp are at the Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

    • Joel R Neilson
    •  & Phillip A Sharp

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Correspondence to Phillip A Sharp.

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DOI

https://doi.org/10.1038/nmeth0405-252

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