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To affinity and beyond

Nature Methods volume 2, page 243 (2005) | Download Citation



A quick, sensitive screen for identifying the binding preferences of protein kinases for various compounds has made it possible to assemble detailed interaction maps, with initial data revealing surprising and important ramifications for drug design.

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    et al. A small molecule–kinase interaction map for clinical kinase inhibitors. Nat. Biotechnol. 23, 329–336 (2005).

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    et al. The protein kinase complement of the human genome. Science 298, 1912–1934 (2002).

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