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Controlling proteins the intein way

Nature Methods volume 4, pages 112113 (2007) | Download Citation



Several methods have been described recently that permit researchers to exert post-translational control over gene products. An intein-based method shows it is a strong contender in the field by demonstrating control of protein activity in a whole animal.

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    & Protein splicing triggered by a small molecule. J. Am. Chem. Soc. 124, 9044–9045 (2002).

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    et al. Post-translational enzyme activation in an animal via optimized conditional protein splicing. Nat. Chem. Biol. 3, 50–54 (2007).

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