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The mysteries of induced pluripotency: where will they lead?

The discovery that it is possible to render somatic cells pluripotent by the exogenous expression of a set of transcription factors provides an experimental model for studying the molecular nature of cellular identity.

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Figure 1: The epigenetic landscape proposed by C.H. Waddington.
Figure 2: 'Secondary' fibroblasts isolated from chimeric embryos made with iPS cells respond efficiently to reprogramming factor induction.
Figure 3: Proposed phases, transition points and cell fates during reprogramming to iPS cells.


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Correspondence to Andras Nagy or Kristina Nagy.

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Nagy, A., Nagy, K. The mysteries of induced pluripotency: where will they lead?. Nat Methods 7, 22–24 (2010).

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