A combination of heat denaturation and mass spectrometry is applied to monitor protein-complex dynamics in the cell.
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References
Tan, C.S.H. et al. Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells. Science 359, 1170–1177 (2018).
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Doerr, A. Heating up cells to bring down complexes. Nat Methods 15, 242–243 (2018). https://doi.org/10.1038/nmeth.4655
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DOI: https://doi.org/10.1038/nmeth.4655