Cellular engineering that allows budding yeast to survive with the four core human histones opens the door to exploring the function of histone variants and their modifications.
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References
Truong, D.M. & Boeke, J.D. Resetting the yeast epigenome with human nucleosomes. Cell 171, 1508–1519 (2017).
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Rusk, N. Humanized yeast—erasing 1.3 billion years of evolution. Nat Methods 15, 96–97 (2018). https://doi.org/10.1038/nmeth.4598
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DOI: https://doi.org/10.1038/nmeth.4598