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Mass spectrometry imaging goes three dimensional

Nature Methods volume 14, pages 1139–1140 (2017)Cite this article

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Two complementary approaches improve 3D mass spectrometry imaging of biomolecules on 3D surfaces and within tissue sections and single cells.

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Figure 1: The functional principles of MALDI MSI with laser triangulation and 3D OrbiSIMS.

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References

  1. Alberts, B. et al. Molecular Biology of the Cell 6th edn. (Garland Science, 2015).

    Google Scholar 

  2. Kompauer, M., Heiles, S. & Spengler, B. Nat. Methods 14, 1156–1158 (2017).

    Article  CAS  Google Scholar 

  3. Passarelli, M.K. et al. Nat. Methods 14, 1175–1183 (2017).

    Article  CAS  Google Scholar 

  4. Norris, J.L. & Caprioli, R.M. Chem. Rev. 113, 2309–2342 (2013).

    Article  CAS  Google Scholar 

  5. Soltwisch, J. et al. Science 348, 211–215 (2015).

    Article  CAS  Google Scholar 

  6. Cole, L. (Ed.) Imaging Mass Spectrometry: Methods and Protocols (Springer, 2017).

    Book  Google Scholar 

  7. Kompauer, M. Nat. Methods 14, 90–96 (2017).

    Article  CAS  Google Scholar 

  8. Zavalin, A., Yang, J., Hayden, K., Vestal, M. & Caprioli, R.M. Anal. Bioanal. Chem. 407, 2337–2342 (2015).

    Article  CAS  Google Scholar 

  9. Bartels, B. et al. RSC Adv. 7, 9045–9050 (2017).

    Article  CAS  Google Scholar 

  10. Fletcher, J.S. & Vickerman, J.C. Anal. Bioanal. Chem. 396, 85–104 (2010).

    Article  CAS  Google Scholar 

  11. Zamboni, N., Saghatelian, A. & Patti, G.J. Mol. Cell 58, 699–706 (2015).

    Article  CAS  Google Scholar 

  12. Oetjen, J. et al. Gigascience 4, 1–8 (2015).

    Article  Google Scholar 

  13. Rzagalinski, I. & Volmer, D.A. Biochim. Biophys. Acta 1865, 726–739 (2017).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Hygiene and the Interdisciplinary Center for Clinical Research (IZKF), University of Münster, Münster, Germany

    Klaus Dreisewerd

  2. Pacific Biosciences Research Center, University of Hawai'i at Mānoa, Honolulu, Hawai'i, USA

    Joanne Y Yew

Authors
  1. Klaus Dreisewerd
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  2. Joanne Y Yew
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Correspondence to Klaus Dreisewerd.

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Dreisewerd, K., Yew, J. Mass spectrometry imaging goes three dimensional. Nat Methods 14, 1139–1140 (2017). https://doi.org/10.1038/nmeth.4513

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