Supplementary Figure 1 : Measuring quaternary structure similarity using global versus local measures.

From: PDB-wide identification of biological assemblies from conserved quaternary structure geometry

Supplementary Figure 1

(a) Structural similarity of two protein complexes can be inferred from a global superposition, which yields a global score, as was done in this work. (b) Structural similarity can also be assessed at the level of pairwise interfaces1–14, but such information would have to be integrated to infer a global similarity measure when complexes contain multiple interfaces. For example, in the case of a tetramer with four interfaces, four similarity measures will be obtained and this number would increase further when comparing complexes with more subunits.