Developments in data-independent-acquisition mass spectrometry allow efficient and accurate quantitation of peptidoforms across large sample cohorts.
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References
Rosenberger, G. et al. Inference and quantification of peptidoforms in large sample cohorts by SWATH-MS. Nat. Biotechnol. http://dx.doi.org/10.1038/nbt.3908 (2017).
Meyer, J.G. et al. PIQED: automated identification and quantification of protein modifications from DIA-MS data. Nat. Methods 14, 646–647 (2017).
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Larochelle, S. Bottoms-up!. Nat Methods 14, 764–765 (2017). https://doi.org/10.1038/nmeth.4383
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DOI: https://doi.org/10.1038/nmeth.4383