Nanobodies that are stable only in the presence of their antigen can be harnessed to manipulate or detect antigen-expressing cells.
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References
Tang, J.C.Y. et al. Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies. eLife 5, e15312 (2016).
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Vogt, N. Conditional nanobody tools. Nat Methods 13, 610–611 (2016). https://doi.org/10.1038/nmeth.3950
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DOI: https://doi.org/10.1038/nmeth.3950