Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A glance at N6-methyladenosine in transcript isoforms

Nature Methods volume 13, pages 624–625 (2016)Cite this article

Subjects

A sequencing approach, m6A-LAIC-seq, globally quantifies the proportion of m6A-modified transcripts of a specific gene and the differential m6A modification levels among its isoforms.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Depicting signatures of the m6A epitranscriptome.

References

  1. He, C. Nat. Chem. Biol. 6, 863–865 (2010).

    Article  CAS  Google Scholar 

  2. Jia, G. et al. Nat. Chem. Biol. 7, 885–887 (2011).

    Article  CAS  Google Scholar 

  3. Zheng, G. et al. Mol. Cell 49, 18–29 (2013).

    Article  CAS  Google Scholar 

  4. Dominissini, D. et al. Nature 485, 201–206 (2012).

    Article  CAS  Google Scholar 

  5. Meyer, K.D. et al. Cell 149, 1635–1646 (2012).

    Article  CAS  Google Scholar 

  6. Molinie, B. et al. Nat. Methods 13, 692–698 (2016).

    Article  CAS  Google Scholar 

  7. Chen, K. et al. Angew. Chem. Int. Ed. 54, 1587–1590 (2015).

    Article  CAS  Google Scholar 

  8. Linder, B. et al. Nat. Methods 12, 767–772 (2015).

    Article  CAS  Google Scholar 

  9. Ke, S. et al. Genes Dev. 29, 2037–2053 (2015).

    Article  CAS  Google Scholar 

  10. Dominissini, D. et al. Nature 530, 441–446 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hailing Shi is at the Department of Chemistry, The University of Chicago, Chicago, Illinois, USA.,

    Hailing Shi

  2. Chuan He is at the Department of Chemistry, the Department of Biochemistry and Molecular Biology, the Institute for Biophysical Dynamics, and the Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois, USA.,

    Chuan He

Authors
  1. Hailing Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chuan He
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chuan He.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shi, H., He, C. A glance at N6-methyladenosine in transcript isoforms. Nat Methods 13, 624–625 (2016). https://doi.org/10.1038/nmeth.3928

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth.3928

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing